English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

The number of obese people worldwide is directly associated with the increased prevalence of Non-Alcoholic Fat Liver Disease (NAFLD), a disease characterized by triglycerides accumulation in the liver. Hepatic lipid metabolism may be regulated by microRNAs (miRs) expression. miR-122 is the most expressed miR in the liver and, among other functions, it regulates glucose and lipid metabolism. Insulin resistance appears to be a common event of NAFLD and obesity, since it underlies the genesis of both diseases. Therefore, the aim of the present study was to investigate a possible connection between insulin resistance, obesity, NAFLD development and alterations in miR-122 hepatic expression in mice fed with HFD for different periods.

anais do congresso de iniciação científica da unicamp

Evaluation of the relationship between weight gain, fat ectopic accumulation in the liver and hepatic expression of miR-122 in mice fed HFD for different periods