Open AccessEvaluation of the relationship between weight gain, fat ectopic accumulation in the liver and hepatic expression of miR-122 in mice fed HFD for different periods
Author(s) -
Carolina Panzarin,
Adriana Souza Torsoni,
Laís Angélica de Paula Simino,
Mariana Camargo Silva Mancini,
Marcela M. Lage,
Marina Figueiredo Fontana,
Marciane Milanski
Publication year - 2017
Publication title -
anais do congresso de iniciação científica da unicamp
Language(s) - English
Resource type - Conference proceedings
ISSN - 2447-5114
DOI - 10.19146/pibic-2017-78587
Subject(s) - ectopic expression , medicine , endocrinology , expression (computer science) , liver tissue , biology , computer science , gene , biochemistry , programming language
The number of obese people worldwide is directly associated with the increased prevalence of Non-Alcoholic Fat Liver Disease (NAFLD), a disease characterized by triglycerides accumulation in the liver. Hepatic lipid metabolism may be regulated by microRNAs (miRs) expression. miR-122 is the most expressed miR in the liver and, among other functions, it regulates glucose and lipid metabolism. Insulin resistance appears to be a common event of NAFLD and obesity, since it underlies the genesis of both diseases. Therefore, the aim of the present study was to investigate a possible connection between insulin resistance, obesity, NAFLD development and alterations in miR-122 hepatic expression in mice fed with HFD for different periods.
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