Gastrorresistant bio-hybrid beads for indomethacin delivery aiming the oral route

Indomethacin is a non-steroidal anti-inflammatory used for many disorders. The oral preferred route causes severe side effects in the gastrointestinal tract, which is exacerbated in chronic diseases, once that a continued administration is necessary. In this work, our goal is the development of a multifunctional solid pharmaceutical form composed of a Nanostructured Lipid Carrier (NLC) prepared with coconut oil further incorporated in (chitosan and xanthan) biopolymers, which combined additional properties to the pharmaceutical form. The resultant bio-hybrids beads were successfully prepared, NLC long-term stability (followed by a year at room temperature), excellent swelling properties and in vitro sustained release profile, for up to 26 hours simulating physiological conditions. These multifaceted bio-hybrid beads seem to be promising for the oral administration of indomethacin in the treatment of chronic inflammatory diseases.