Synthesis of Quinazoline Derivatives for Adenosine Kinase Inhibition | Zendy

Gabriela Guerreiro Souzedo | Zendy; Ljubica Tasić | Zendy; Caio H. N. Barros | Zendy

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Synthesis of Quinazoline Derivatives for Adenosine Kinase Inhibition

Author(s) -

Gabriela Guerreiro Souzedo,

Ljubica Tasić,

Caio H. N. Barros

Publication year - 2017

Publication title -

anais do congresso de iniciação científica da unicamp

Language(s) - English

Resource type - Conference proceedings

ISSN - 2447-5114

DOI - 10.19146/pibic-2017-78452

Subject(s) - adenosine kinase , quinazoline , adenosine , chemistry , pharmacology , combinatorial chemistry , biochemistry , medicine , adenosine deaminase

The project consists in the development of three anilinoquinazoline synthetic derivatives (3-bromoanilinoquinazoline, 4iodoanilinoquinazoline and 4-acetateanilinoquinazoline), by simple synthesis methods – ciclization, halogenation and eletrophilic aromatic substitution – with aplication on adenosine kinase (ADK) inhibition, which is linked with the prevention of many diseases, such as infarct, stroke and others.

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