Open AccessBupivacaine-loaded nanoparticulated lipid carrriers prepared with beeswax and melaleuca oil aiming the treatment of burn injuries: in vitro release study
Author(s) -
Gabriela Gerônimo,
Eneida de Paula,
Gustavo H. Rodrigues da Silva,
Lígia Nunes de Morais Ribeiro,
Márcia Cristina Breitkreitz
Publication year - 2017
Publication title -
anais do congresso de iniciação científica da unicamp
Language(s) - English
Resource type - Conference proceedings
ISSN - 2447-5114
DOI - 10.19146/pibic-2017-78171
Subject(s) - beeswax , melaleuca , in vitro , bupivacaine , chemistry , pharmacology , medicine , wax , organic chemistry , biochemistry , biology , botany
Pain control in burn injuries is still inadequate and deserves improvement. For this, we have prepared an innovative formulation of nanoparticle lipid carriers (NLC) containing 1% bupivacaine (S75:R25, herein, BVC). The NLC were composed of beeswax and melaleuca oil. In vitro release tests showed a prolonged release (over 25 hours), confirming the preparation of a sustained drug-delivery system (DDS) for the local anesthetic. The formulation developed is promising for the next (in vivo tests, hydridization) steps of research, towards a long-lasting, topical painkiller.
Accelerating Research
Robert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom
Address
John Eccles HouseRobert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom