ENDOTHELIAL MODULATION DURING OROPOUCHE VIRUS INFECTION | Zendy

Pierina Lorencini Parise | Zendy; José Luiz ProençaMódena | Zendy

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ENDOTHELIAL MODULATION DURING OROPOUCHE VIRUS INFECTION

Author(s) -

Pierina Lorencini Parise,

José Luiz ProençaMódena

Publication year - 2017

Publication title -

anais do congresso de iniciação científica da unicamp

Language(s) - English

Resource type - Conference proceedings

ISSN - 2447-5114

DOI - 10.19146/pibic-2017-77968

Subject(s) - virology , modulation (music) , computer science , physics , medicine , acoustics

ENDOTHELIAL MODULATION DURING OROPOUCHE VIRUS INFECTION Pierina L. Parise*, Guilherme P. Milanez, Daniel A. T. Teixeira, Mariene R. Amorin, Felipe R. Santos, Carla C. Judice, Rosemeire F. Paula, Fabio T. M. Costa, Marco A. R. Vinolo, José L. P. Modena Abstract In this project we showed that Oropouche vírus (OROV) productively infect human umbilical vein endothelial cells (HUVEC). In addition, we demonstrated that this virus modulates the production of vasoactive cytokines, such as TNF-α and IL-6, and endothelial adhesion molecules, such as ICAM-1, e-selectin and eNOS. These data bring new insights how OROV can cross the blood-placental barrier.

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