Serine protease from Bothrops asper snake venom and its inhibition in the presence of hesperitin | Zendy

Giovanna Rivabem Grillo | Zendy; Ljubica Tasić | Zendy; Roney Vander Dos Santos | Zendy

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Serine protease from Bothrops asper snake venom and its inhibition in the presence of hesperitin

Author(s) -

Giovanna Rivabem Grillo,

Ljubica Tasić,

Roney Vander Dos Santos

Publication year - 2017

Publication title -

anais do congresso de iniciação científica da unicamp

Language(s) - English

Resource type - Conference proceedings

ISSN - 2447-5114

DOI - 10.19146/pibic-2017-77913

Subject(s) - serine protease , venom , snake venom , bothrops , protease , serine , chemistry , biochemistry , enzyme

Our studies focus on the biochemical activity of a serine protease, named BaSP1 (Bothrops asper Serine Protease 1), derived from Bothrops asper snake venom; in the presence of hesperitin, a flavonoid obtained by the hydrolysis of hesperidin, which was obtained from citrus peel or juice. We obtained indications that hesperitin acts as an inhibitor of BaSP1. In order to evaluate the interactions between inhibitor and enzyme, circular dichroism, fluorescence spectroscopy and enzymatic assays were performed.

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