Hydrogen-1 Nuclear Magnetic Resonance Spectroscopy applied to metabolomics of the crack users and patientis with schizophrenia

This research aims to compare metabolomic profiles of blood serum samples of healthy people (HC) to those who are addicted to crack and seconderaly, metabolomic profiles of blood serum samples of patientis with schizophrenia (SCZ) to those addicted to crack using nuclear magnetic resonance spectroscopy (1H NMR). 1H NMR data shall be then treated using chemometric tools such as principal component analysis (PCA) aiming to differentiate two groups of samples and enable identification of NMR spectral regions important for the metabolic differences. Further, biomarkers for crack dependence might be identified and, thus, improve clinical diagnosis and discovery of new pharmacological and therapeutic interventions in this drug dependence treatment. A differential diagnosis may be used to differentiate the symptoms caused by the crack dependence to the positive symptoms of schizophrenia patients, such as psychosis.