Action of the Epigallocatechin-3-gallate (EGCG) on the inflammation on tenocytes culture | Zendy

Mariana Bombardi Da Silva | Zendy; Edson Rosa Pimentel | Zendy; Cristiano Pedrozo Vieira | Zendy; Letícia Prado de Oliveira | Zendy; Giane Daniela Carneiro | Zendy; Cristina Pontes Vicente | Zendy

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Action of the Epigallocatechin-3-gallate (EGCG) on the inflammation on tenocytes culture

Author(s) -

Mariana Bombardi Da Silva,

Edson Rosa Pimentel,

Cristiano Pedrozo Vieira,

Letícia Prado de Oliveira,

Giane Daniela Carneiro,

Cristina Pontes Vicente

Publication year - 2016

Publication title -

anais do congresso de iniciação científica da unicamp

Language(s) - English

Resource type - Conference proceedings

ISSN - 2447-5114

DOI - 10.19146/pibic-2016-52121

Subject(s) - epigallocatechin gallate , gallate , action (physics) , inflammation , chemistry , pharmacology , polyphenol , medicine , biochemistry , antioxidant , physics , quantum mechanics

The Epigallocatechin-3-gallate (EGCG) is the most important compound of the green tea. This study analyzed tenocytes in vitro inflammed with TNF-α focusing the activity of metalloproteinases (MMP)-2, -8, and -9. On the medium cell, groups treated with EGCG showed lower quantites of MMP -2 and -9. Tenocyte zymography demonstrate presence of MMP -2, -8 and -9 in treated and non-treated groups. Nevertheless, inflammed groups display larger quantities of those MMPs. This study indicate improvement on the inflammatory process in groups treated with EGCG.

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