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Cystic Fibrosis (CF) is a serious genetic disease, CF is an autosomal recessive genetic disease clinical manifestations can vary being detectable after birth or in adulthood. Basically the defect affects the cells of various organs , which can be presented in different ways in individuals with the disease. With this research can therefore conclude that the alpha-1 antitrypsin deficiency is an aggravating factor for lung disease in people with cystic fibrosis.

As the deficiency of alpha-1 antitrypsin glycoprotein affects the severity of lung disease among patients with Cystic Fibrosis