Incorporation of AgSD in KGM asymmetric membranes for wound dressing

The development of effective and accessible treatment for 2nd degree burns is rather relevant because of the high frequency of accidents involving this kind of injury in domestic and work environment. The objectives of this project were to produce and evaluate silver sulfadiazine (AgSD) loaded konjac glucomannan (KGM) membranes as potential wound dressings for the treatment of 2nd degree burns. Thermal analysis revealed that sulfadiazine forms hydrogen bonds with the hydroxyl groups of KGM and that silver ions reduce to metallic silver microparticles at low temperatures. However, atomic absorption showed that a significant portion of the incorporated silver was lost in the water used to neutralize the pH of the membranes.