Role of ARHGAP21 on cell proliferation in C57BL/6 mouse islets | Zendy

ELIS GUIMARAES DE AZEVEDO | Zendy; Helena Sampaio | Zendy; Gabriela Moreira Soares | Zendy; MATHEUS DOMINGOS TERRAZAM | Zendy; Sara Teresinha Olalla Saad | Zendy; Antonio Carlos Boschiero | Zendy

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Role of ARHGAP21 on cell proliferation in C57BL/6 mouse islets

Author(s) -

ELIS GUIMARAES DE AZEVEDO,

Helena Sampaio,

Gabriela Moreira Soares,

MATHEUS DOMINGOS TERRAZAM,

Sara Teresinha Olalla Saad,

Antonio Carlos Boschiero

Publication year - 2016

Publication title -

anais do congresso de iniciação científica da unicamp

Language(s) - English

Resource type - Conference proceedings

ISSN - 2447-5114

DOI - 10.19146/pibic-2016-51765

Subject(s) - islet , cell growth , microbiology and biotechnology , cell , biology , endocrinology , diabetes mellitus , genetics

ARHGAP21 participates in cell proliferation, but the mechanisms involved in the role of that GAP are not elucidated. This project aims to investigate the possible involvement of ARHGAP21 in beta cell proliferation mechanisms in pancreatic islet in response to insulin resistance in ARGAP21 haplodeficient mice, after administration of a high fat diet. This project contributes to understanding the cellular mechanisms that lead beta cell mass and proliferation in insulin resistance.

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