Characterization of methylation profile during progression of Wilms tumors | Zendy

João Victor da Silva Guerra | Zendy; Mariana Maschietto | Zendy; Rafaela Montalvão-de-Azevedo | Zendy; Paulo Antônio Silvestre de Faria | Zendy; Beatriz de Camargo | Zendy

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Characterization of methylation profile during progression of Wilms tumors

Author(s) -

João Victor da Silva Guerra,

Mariana Maschietto,

Rafaela Montalvão-de-Azevedo,

Paulo Antônio Silvestre de Faria,

Beatriz de Camargo

Publication year - 2016

Publication title -

anais do congresso de iniciação científica da unicamp

Language(s) - English

Resource type - Conference proceedings

ISSN - 2447-5114

DOI - 10.19146/pibic-2016-51604

Subject(s) - wilms' tumor , wilms tumour , methylation , computer science , characterization (materials science) , cancer research , medicine , biology , materials science , pathology , genetics , nanotechnology , gene

Wilms tumors (WTs) are the most common renal tumors with a relapse rate of ~25%, from which long-term survival remains approximately 50%. The ability of relapsing is associated with resistance to chemotherapy and capacity of forming distant metastasis. Because in DNA methylation has being correlated with tumor cells plasticity, we purposed to characterize DNA methylation changes in normal kidney (NK), WT and distant metastasis to identify the mechanisms involved with tumor progression and resistance.

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