Study of the relationship between the proteins Nucleophosmin-1 and Nucleolin and different S6Ks isoforms | Zendy

Fernando Riback Silva | Zendy; Fernando Moreira Simabuco | Zendy; Isadora Carolina Betim Pavan | Zendy; Ana Paula Morelli | Zendy

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Study of the relationship between the proteins Nucleophosmin-1 and Nucleolin and different S6Ks isoforms

Author(s) -

Fernando Riback Silva,

Fernando Moreira Simabuco,

Isadora Carolina Betim Pavan,

Ana Paula Morelli

Publication year - 2016

Publication title -

anais do congresso de iniciação científica da unicamp

Language(s) - English

Resource type - Conference proceedings

ISSN - 2447-5114

DOI - 10.19146/pibic-2016-51492

Subject(s) - nucleophosmin , nucleolin , gene isoform , focus (optics) , microbiology and biotechnology , computational biology , chemistry , computer science , biochemistry , biology , cytoplasm , gene , nucleolus , physics , optics

The mTOR signaling pathway has been related to several diseases and metabolic disorders in humans, including obesity, diabetes and various types of cancer. The S6Ks proteins have shown important roles in the signaling of mTOR, acting as effectors of this pathway, but there are still open questions, such as their functional differences and interacting proteins. The aim of this study was to investigate the possible relationship between the proteins Nucleophosmin1 (NPM1) and Nucleolin (NCL), involved with cell proliferation, biogeneses of ribossomes and protein syntesis, and the

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