Controlled Drug Release by Amphiphilic Polyurethane Hydrogels | Zendy

Lucas Polo Fonseca | Zendy; Maria I. Felisberti | Zendy; Rafael Bergamo Trinca | Zendy

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Controlled Drug Release by Amphiphilic Polyurethane Hydrogels

Author(s) -

Lucas Polo Fonseca,

Maria I. Felisberti,

Rafael Bergamo Trinca

Publication year - 2016

Publication title -

anais do congresso de iniciação científica da unicamp

Language(s) - English

Resource type - Conference proceedings

ISSN - 2447-5114

DOI - 10.19146/pibic-2016-51248

Subject(s) - amphiphile , polyurethane , self healing hydrogels , drug , materials science , chemistry , chemical engineering , polymer chemistry , copolymer , composite material , pharmacology , polymer , engineering , medicine

Amphiphilic polyurethanes (PU), composed by PEG as hydrophilic segment and PCL-triol as hydrophobic crosslinking agent, were loaded with sodium diclofenac, a anti-inflammatory drug, using ethanol solutions. The drug release in PBS buffer solution was investigated. The sodium diclofenac sorption in the hydrogels increased with the drug concentration in the loading solutions and decreased with increasing crosslinking density of the hydrogels. The drug release in PBS solutions achieved a linear dependence with time after 50 minutes of water swelling, indicating a controlled release behaviour.

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