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Resumo Studies show that the high fat diet (HFD) exposure during gestation and lactation promotes obesogenic effects in offspring, such as the increase in the intracellular inflammatory signaling. Studies show that activation of α7nAChR by nicotine suppresses the inflammation in adipose tissue and improves the insulin sensitivity in animal model of obesity. The Offspring (28 days) of mothers fed high-fat diet during pregnancy and lactation showed reduced expression of cholinergic receptor α7nAChR in adipose tissue and hypothalamic. This reduction may contribute to an energy imbalance and increased predisposition to obesity.

anais do congresso de iniciação científica da unicamp

EVALUATION OF CHOLINERGIC ANTI-INFLAMMATORY PATHWAY IN THE HYPOTHALAMUS AND WHITE ADIPOSE TISSUE OF OFFSPRING MICE WITH OBESITY INDUCED BY MATERNAL CONSUMPTION OF HIGH FAT DIET