EVALUATION OF CHOLINERGIC ANTI-INFLAMMATORY PATHWAY IN THE HYPOTHALAMUS AND WHITE ADIPOSE TISSUE OF OFFSPRING MICE WITH OBESITY INDUCED BY MATERNAL CONSUMPTION OF HIGH FAT DIET | Zendy

CAMILLA M. SOUZA | Zendy; Márcio Alberto Torsoni | Zendy; JULIA DE OLIVEIRA SARTORI | Zendy; PÂMELA G. LANZA | Zendy; Suleyma O. Costa | Zendy; Simone Ferreira Lemes | Zendy; ANELISE C. P. SOUZA | Zendy; Adriana Souza Torsoni | Zendy; Marciane Milanski | Zendy; Tamires dos Santos | Zendy

Open Access

EVALUATION OF CHOLINERGIC ANTI-INFLAMMATORY PATHWAY IN THE HYPOTHALAMUS AND WHITE ADIPOSE TISSUE OF OFFSPRING MICE WITH OBESITY INDUCED BY MATERNAL CONSUMPTION OF HIGH FAT DIET

Author(s) -

CAMILLA M. SOUZA,

Márcio Alberto Torsoni,

JULIA DE OLIVEIRA SARTORI,

PÂMELA G. LANZA,

Suleyma O. Costa,

Simone Ferreira Lemes,

ANELISE C. P. SOUZA,

Adriana Souza Torsoni,

Marciane Milanski,

Tamires dos Santos

Publication year - 2016

Publication title -

anais do congresso de iniciação científica da unicamp

Language(s) - English

Resource type - Conference proceedings

ISSN - 2447-5114

DOI - 10.19146/pibic-2016-51047

Subject(s) - offspring , white adipose tissue , adipose tissue , hypothalamus , cholinergic , obesity , endocrinology , medicine , consumption (sociology) , biology , pregnancy , genetics , social science , sociology

Resumo Studies show that the high fat diet (HFD) exposure during gestation and lactation promotes obesogenic effects in offspring, such as the increase in the intracellular inflammatory signaling. Studies show that activation of α7nAChR by nicotine suppresses the inflammation in adipose tissue and improves the insulin sensitivity in animal model of obesity. The Offspring (28 days) of mothers fed high-fat diet during pregnancy and lactation showed reduced expression of cholinergic receptor α7nAChR in adipose tissue and hypothalamic. This reduction may contribute to an energy imbalance and increased predisposition to obesity.

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