Enantioselective Hydrolysis of 1-Aryl-2-chloroethyl propanoate Mediated by Burkholderia cepacia and Candida rugosa Lipases. | Zendy

PRISCILA SANTOS DE OLIVEIRA | Zendy; Paulo J. S. Moran | Zendy; Lucidio Cristovão Fardelone | Zendy; J. Augusto R. Rodrigues | Zendy

Open Access

Enantioselective Hydrolysis of 1-Aryl-2-chloroethyl propanoate Mediated by Burkholderia cepacia and Candida rugosa Lipases.

Author(s) -

PRISCILA SANTOS DE OLIVEIRA,

Paulo J. S. Moran,

Lucidio Cristovão Fardelone,

J. Augusto R. Rodrigues

Publication year - 2016

Publication title -

anais do congresso de iniciação científica da unicamp

Language(s) - English

Resource type - Conference proceedings

ISSN - 2447-5114

DOI - 10.19146/pibic-2016-50943

Subject(s) - candida rugosa , enantioselective synthesis , burkholderia , hydrolysis , aryl , lipase , chemistry , organic chemistry , catalysis , biology , bacteria , enzyme , alkyl , genetics

Enantioselective hydrolysis of racemic compounds 4a-b by lipases from Burkholderia cepacia and Candida rugosa afforded the corresponding alcohols in 79-91%, isolated yield, that can be used as building blocks for stereoselective syntheses of pharmaceuticals compounds as Sotalol and Sertraline.

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