Effects of the Immunomodulator P-MAPA in the Treatment of Non-Muscle Invasive Bladder Cancer: Interfaces between Energy Metabolism and Angiogenesis | Zendy

Melina de Moraes Santos Oliveira | Zendy; Petra Karla Böckelmann | Zendy; Patrick Vianna Garcia | Zendy; Wagner José Fávaro | Zendy

Open Access

Effects of the Immunomodulator P-MAPA in the Treatment of Non-Muscle Invasive Bladder Cancer: Interfaces between Energy Metabolism and Angiogenesis

Author(s) -

Melina de Moraes Santos Oliveira,

Petra Karla Böckelmann,

Patrick Vianna Garcia,

Wagner José Fávaro

Publication year - 2016

Publication title -

anais do congresso de iniciação científica da unicamp

Language(s) - English

Resource type - Conference proceedings

ISSN - 2447-5114

DOI - 10.19146/pibic-2016-50828

Subject(s) - bladder cancer , angiogenesis , energy metabolism , cancer research , metabolism , cancer , medicine , urology , oncology

In the neoplastic disease, adjustments in cellular energy metabolism are needed to stimulate cell division and therapies that work in these settings are a new therapeutic modality, as the immunomodulator P-MAPA. Thus, the objectives of this study were to characterize the histopathologic and molecular effects of immunotherapies with BCG and P-MAPA in the treatment of bladder cancer in rats and to establish possible mechanisms of action of these therapies involving cellular energy metabolism.

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