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In the neoplastic disease, adjustments in cellular energy metabolism are needed to stimulate cell division and therapies that work in these settings are a new therapeutic modality, as the immunomodulator P-MAPA. Thus, the objectives of this study were to characterize the histopathologic and molecular effects of immunotherapies with BCG and P-MAPA in the treatment of bladder cancer in rats and to establish possible mechanisms of action of these therapies involving cellular energy metabolism.

Effects of the Immunomodulator P-MAPA in the Treatment of Non-Muscle Invasive Bladder Cancer: Interfaces between Energy Metabolism and Angiogenesis