PENGARUH NATRIUM SIKLAMAT TERHADAP HISTOPATOLOGI ORGAN MENCIT (Mus musculus) DAN SUMBANGSIHNYA PADA MATERI STRUKTUR DAN FUNGSI JARINGAN HEWAN DI SMA/MA

Sweeteners are one of the components which are often added to foodstuffs. Synthetic sweeteners are widely used in the society is sodium cyclamate. The purpose of this study was to determine the sodium cyclamate on the histological structure of the glomerulus of mice (Mus musculus). This research used 12 male mice (Mus musculus) with Completely Randomized Design (CRD) so there are 4 groups (control, PI: 0,55 mg/grbb, p2: 1,1 mg/grbb, and p3: 1,65 mg/grbb) with 3 replications for 24 days. Parameters observed were edema and comparison of area glomerulus with Bowman capsule. The result showed that sodium cyclamate had effect to edema and tended to area glomerulus with Bowman capsule comparization. Based on the research could be concluded that sodium cyclamate had effect to renal histopathology. This research will be used as media in learning process.