Heart Regeneration with Embryonic Cardiac Progenitor Cells and Cardiac Tissue Engineering | Zendy

Shuo Tian | Zendy; Qihai Liu | Zendy; Leonid Gnatovskiy | Zendy; X. Peter | Zendy; Zhong Wang | Zendy

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Heart Regeneration with Embryonic Cardiac Progenitor Cells and Cardiac Tissue Engineering

Author(s) -

Shuo Tian,

Qihai Liu,

Leonid Gnatovskiy,

X. Peter,

Zhong Wang

Publication year - 2015

Publication title -

journal of stem cell and transplantation biology

Language(s) - English

Resource type - Journals

ISSN - 2469-5157

DOI - 10.19104/jstb.2015.104

Subject(s) - regeneration (biology) , tissue engineering , stem cell , myocardial infarction , embryonic stem cell , progenitor cell , medicine , cardiac function curve , stem cell therapy , cell therapy , heart failure , cardiology , biology , microbiology and biotechnology , biomedical engineering , biochemistry , gene

Myocardial infarction (MI) is the leading cause of death worldwide. Recent advances in stem cell research hold great potential for heart tissue regeneration through stem cell-based therapy. While multiple cell types have been transplanted into MI heart in preclinical studies or clinical trials, reduction of scar tissue and restoration of cardiac function have been modest. Several challenges hamper the development and application of stem cell-based therapy for heart regeneration. Application of cardiac progenitor cells (CPCs) and cardiac tissue engineering for cell therapy has shown great promise to repair damaged heart tissue. This review presents an overview of the current applications of embryonic CPCs and the development of cardiac tissue engineering in regeneration of functional cardiac tissue and reduction of side effects for heart regeneration. We aim to highlight the benefits of the cell therapy by application of CPCs and cardiac tissue engineering during heart regeneration.

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