English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Objective: The objective of this study was to evaluate the biocompatibility of five commercially available orthodontic miniscrews/ temporary anchorage devices. Materials and Methods: A cell culture system using commercially available human gingival fibroblasts was utilized. Miniscrews/ temporary anchorage devices obtained from Ormco, Ortho Organizer, 3M Unitek, American Orthodontics, and Rocky Mountain Orthodontics were immersed in culture medium for either 48 hours or two weeks. The surface area to volume character of the eluates produced by this method was within the suggested ISO range. Gingival fibroblasts were exposed to miniscrew/temporary anchorage device conditioned culture medium for 24 hours. Biocompatibility and cytotoxicity were measured using colorimetric 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) and lactate dehydrogenase (LDH) assays. Results were analyzed using ANOVA with Tukey’s post-test and P 0.05 for all comparisons). MTT analysis, used to quantify viable cells, demonstrated that 48 hour conditioned medium significantly affected cell viability (P < 0.001 for all treatments compared to control). In contrast two week conditioned medium from all five devices did not affect cell viability compared to control. Conclusion: The results of this study suggest that miniscrews/ temporary anchorage devices demonstrate longer-term biocompatibility with gingival fibroblasts and that the composition of the devices is not cytotoxic to oral cells. The general lack of data regarding the cytotoxicity of miniscrews/temporary anchorage devices in orthodontic treatment warrants further investigation.

Biocompatibility of Temporary Anchorage Devices Using an in vitro Cell Culture Model