Use of Baclofen in the Treatment of Persistent Hiccups: Report of Two Cases

We present two cases of persistent hiccups attributed to lateral medullary syndromes that were refractory to common pharmacological treatment. Introduction of baclofen resulted in the rapid and sustained resolution of hiccups in these patients, with no significant adverse effects noted. Our reports serve to strengthen the limited evidence base for baclofen as a pharmacological agent for treatment of hiccups, and suggest the consideration of its use as a first line treatment specifically in hiccups secondary to lateral medullary infarcts.