Variations in ADIPOR1 But Not ADIPOR2 are Associated With Hypertriglyceridemia and Diabetes in an Admixed Latin American Population | Zendy

Gustavo Mora-García | Zendy; M. Ruiz | Zendy; Fabián Espitia-Almeida | Zendy; Doris GómezCamargo | Zendy

Open Access

Variations in ADIPOR1 But Not ADIPOR2 are Associated With Hypertriglyceridemia and Diabetes in an Admixed Latin American Population

Author(s) -

Gustavo Mora-García,

M. Ruiz,

Fabián Espitia-Almeida,

Doris GómezCamargo

Publication year - 2017

Publication title -

the review of diabetic studies

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.701

H-Index - 41

eISSN - 1614-0575

pISSN - 1613-6071

DOI - 10.1900/rds.2017.14.311

Subject(s) - hypertriglyceridemia , single nucleotide polymorphism , adiponectin , medicine , insulin resistance , diabetes mellitus , endocrinology , population , metabolic syndrome , genome wide association study , biology , triglyceride , genetics , cholesterol , genotype , gene , environmental health

Adiponectin is a hormone secreted by adipose tissue. It regulates glycolysis and lipolysis and is involved in the pathophysiology of diabetes and related disorders. Its activity is mainly mediated by the transmembrane receptors AdipoR1 and AdipoR2, which are encoded by ADIPOR1 (1q32.1) and ADIPOR2 (12p13.33) genes, respectively. In genetic association studies, single nucleotide polymorphisms (SNPs) in or near these genes have been associated with metabolic alterations. However, these relationships are still controversial.

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