The rs11705701 G>A Polymorphism of IGF2BP2 is Associated With IGF2BP2 mRNA and Protein Levels in the Visceral Adipose Tissue - A Link to Type 2 Diabetes Susceptibility | Zendy

Dimitry A. Chistiakov | Zendy; Alexey G. Nikitin | Zendy; С. А. Сметанина | Zendy; Лариса Николаевна Бельчикова | Zendy; Л. А. Суплотова | Zendy; М. В. Шестакова | Zendy; В. В. Носиков | Zendy

Open Access

The rs11705701 G>A Polymorphism of IGF2BP2 is Associated With IGF2BP2 mRNA and Protein Levels in the Visceral Adipose Tissue - A Link to Type 2 Diabetes Susceptibility

Author(s) -

Dimitry A. Chistiakov,

Alexey G. Nikitin,

С. А. Сметанина,

Лариса Николаевна Бельчикова,

Л. А. Суплотова,

М. В. Шестакова,

В. В. Носиков

Publication year - 2012

Publication title -

the review of diabetic studies

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.701

H-Index - 41

eISSN - 1614-0575

pISSN - 1613-6071

DOI - 10.1900/rds.2012.9.112

Subject(s) - medicine , type 2 diabetes , endocrinology , body mass index , obesity , odds ratio , biology , diabetes mellitus

Insulin-like growth factor 2 mRNA-binding protein 2 (IGF2BP2) regulates translation of IGF2, a growth factor that plays a key role in controlling fetal growth and organogenesis including adipogenesis and pancreatic development. In Caucasians, the rs4402960 G>T polymorphism of IGF2BP2 has been shown to predispose to type 2 diabetes (T2D) in multiple populations. In this study, we tested whether rs4402960 G>T and rs11705701 G>A contribute to the development of T2D in a Russian population.

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