Open AccessGlucose Homeostasis in Pre-diabetic NOD and Lymphocyte-Deficient NOD/SCID Mice During Gestation
Author(s) -
Josiane Coulaud,
Sylvie Durant,
Françoise HomoDelarche
Publication year - 2010
Publication title -
the review of diabetic studies
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.701
H-Index - 41
eISSN - 1614-0575
pISSN - 1613-6071
DOI - 10.1900/rds.2010.7.36
Subject(s) - nod , homeostasis , gestation , glucose homeostasis , nod mice , lymphocyte , immunology , endocrinology , medicine , biology , diabetes mellitus , pregnancy , insulin resistance , genetics
Unlike other strains, spontaneously type 1 non-obese diabetic (NOD) experience transient hyperinsulinemia after weaning. The same applies for NOD/SCID mice, which lack functional lymphocytes, and unlike NOD mice, do not develop insulitis and diabetes like NOD mice.
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