A WFS1 Haplotype Consisting of the Minor Alleles of rs752854, rs10010131, and rs734312 Shows a Protective Role Against Type 2 Diabetes in Russian Patients | Zendy

Dimitry A. Chistiakov | Zendy; Dmitry Khodyrev | Zendy; С. А. Сметанина | Zendy; Лариса Николаевна Бельчикова | Zendy; Л. А. Суплотова | Zendy; В. В. Носиков | Zendy

Open Access

A WFS1 Haplotype Consisting of the Minor Alleles of rs752854, rs10010131, and rs734312 Shows a Protective Role Against Type 2 Diabetes in Russian Patients

Author(s) -

Dimitry A. Chistiakov,

Dmitry Khodyrev,

С. А. Сметанина,

Лариса Николаевна Бельчикова,

Л. А. Суплотова,

В. В. Носиков

Publication year - 2010

Publication title -

the review of diabetic studies

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.701

H-Index - 41

eISSN - 1614-0575

pISSN - 1613-6071

DOI - 10.1900/rds.2010.7.285

Subject(s) - wolfram syndrome , medicine , type 2 diabetes , diabetes mellitus , haplotype , endocrinology , insulin resistance , allele , minor allele frequency , population , insulin , pathogenesis , body mass index , biology , allele frequency , genetics , gene , environmental health

Rare variants of the WFS1 gene encoding wolframin cause Wolfram syndrome, a monogenic disease associated with diabetes insipidus, diabetes mellitus, optic atrophy, and deafness. In contrast, common variants of WFS1 showed association with type 2 diabetes (T2D) in numerous Caucasian populations.

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