ENPP1 K121Q Polymorphism is not Related to Type 2 Diabetes Mellitus, Features of Metabolic Syndrome, and Diabetic Cardiovascular Complications in a Chinese Population | Zendy

MiaoPei Chen | Zendy; FuMei Chung | Zendy; DaoMing Chang | Zendy; Jack C-R Tsai | Zendy; Han-Fen Huang | Zendy; Shyi–Jang Shin | Zendy; YauJiunn Lee | Zendy

Open Access

ENPP1 K121Q Polymorphism is not Related to Type 2 Diabetes Mellitus, Features of Metabolic Syndrome, and Diabetic Cardiovascular Complications in a Chinese Population

Author(s) -

MiaoPei Chen,

FuMei Chung,

DaoMing Chang,

Jack C-R Tsai,

Han-Fen Huang,

Shyi–Jang Shin,

YauJiunn Lee

Publication year - 2006

Publication title -

the review of diabetic studies

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.701

H-Index - 41

eISSN - 1614-0575

pISSN - 1613-6071

DOI - 10.1900/rds.2006.3.21

Subject(s) - medicine , type 2 diabetes mellitus , type 2 diabetes , endocrinology , diabetes mellitus , population , metabolic syndrome , insulin resistance , allele , insulin , biology , genetics , gene , environmental health

Ectoenzyme nucleotide pyrophosphate phosphodiesterase 1 (ENPP1) is known to influence insulin sensitivity by inhibiting insulin receptor signaling. A DNA polymorphism in the ENPP1 gene at exon 4 (K121Q) was demonstrated to be associated with insulin resistance, type 2 diabetes mellitus (T2DM), and a risk of early myocardial infarction, albeit with controversy. Our aim was to investigate any association of ENPP1 K121Q alleles with T2DM, features of the metabolic syndrome, and diabetic cardiovascular complications in a Chinese population of Han origin.

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