Manganese Superoxide Dismutase Alanine to Valine Polymorphism and Risk of Neuropathy and Nephropathy in Egyptian Type 1 Diabetic Patients | Zendy

Tarek M. El Masry | Zendy; Mona A. M. Abou Zahra | Zendy; Mohammed M. El Tawil | Zendy; Rawhia A. Khalifa | Zendy

Open Access

Manganese Superoxide Dismutase Alanine to Valine Polymorphism and Risk of Neuropathy and Nephropathy in Egyptian Type 1 Diabetic Patients

Author(s) -

Tarek M. El Masry,

Mona A. M. Abou Zahra,

Mohammed M. El Tawil,

Rawhia A. Khalifa

Publication year - 2005

Publication title -

the review of diabetic studies

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.701

H-Index - 41

eISSN - 1614-0575

pISSN - 1613-6071

DOI - 10.1900/rds.2005.2.70

Subject(s) - diabetic nephropathy , sod2 , superoxide dismutase , medicine , population , gene polymorphism , nephropathy , endocrinology , microbiology and biotechnology , diabetes mellitus , genetics , oxidative stress , biology , gene , genotype , environmental health

Oxidative stress, characterized by a marked increase in the level of oxygen free radicals (OFR), has been implicated in the development of diabetic microangiopathic complications, such as diabetic neuropathy (DN) and nephropathy (DP). Antioxidant enzymes may protect against the rapid onset and progression of microangiopathy, by reducing the excess of OFR and peroxides. Mutations and polymorphisms in genes encoding such enzymes may therefore result in a predisposition to this disorder.

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