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infections were E. coli 425 (54.9%), S. aureus 68 (24.9%), Klebsiella spp. 3 (23%), P. aeruginosa 110 (26.9%), and S. aureus 30 (20.4%) respectively. The overall prevalence of resistance to the antimicrobial agents tested in various clinical specimens is discussed in this study. Conclusion: The high resistance rate was observed in our study to most used antibiotics. Therefore, setting up a comprehensive surveillance system is need to evaluate the distribution of organisms isolated and their drug resistance pattern over different period of time and place of Iran.

Prevalence and Antimicrobial Susceptibility Patterns of Bacteria Isolated from Different Clinical Infections in Hamadan, Iran