An in vitro study on anti-sickling activity of Terminalia arjuna and Terminalia bellirica

About five million people yearly in the world are affected by Sickle cell disease (SCD) and approximately 1,00,000 children in the world are born each year with SCD. It is considered as a public health problem, particularly in west and central Africa and Indian subcontinent. (Moody et al., 2003, Mpiana et al., 2007, Mandot et al., 2009). Sickle cell anemia is an autosomal genetic blood disorder where concave blood cells are changed to abnormal sickle shaped red blood cells (RBCs). In sickle hemoglobin, glutamtic acid is replaced by valine in position 6 (Mpiana et al., 2013) causes a reduction in the solubility of sickle cell hemoglobin (HbS) and its polymerization to form a mass of fibres which changes shape of erythrocytes into a sickle shape (Clarke and Pazdernik, 2013). The therapies include Journal of Herbal Drug