Evaluation of the compression process diagram in presence of magnesium stearate

Lubricants are used mainly for compression in tableting. The task of the lubricants exists is the decrease of the size of contact points, as a layer, which possesses even a low shearing strength and will not easily break through can, between which rubbing surfaces is put. The lubricants decrease the range of the reciprocal effect to places, where the surfaces touch themselves, and inhibition of the sliding procedure which increase of the contact points. The distribution of lubricant on the particle surface by one lines up examined by many researchers and the results contradicted to attempt distribution of magnesium stearate particle on substance surface and it is shown that magnesium stearate could not cover the surface as monomolecular coverage (1), but magnesium stearate particle at the granulates surface is adsorbed. The fundamental work for the description of the compression procedure at the tableting originate from the powder metallurgy (2,3), the work for the theory of pressing powdered raw ores from the pharmaceutical range (4,5). In the pharmaceutical industry is no longer worked without instrumented Abstract In the pharmaceutical industry is no longer worked without instrumented tablet presses. The recording of the press information at different parameters of each test series and batches in the development of tablets and an online measurement and control of pressing forces during the production process is becoming increasingly important. Eccentric tablet presses were equipped with sensors for the upper and lower punch force and upper punch way. As sample quantity 100 g were selected. All fillers lubricant mixtures were prepared in Turbula lab mixtures with 68 rpm. The bulk and tap density of the excipients were determined according to DIN of 53912 and 53194 on a tap density testers into a 250 mL graduated cylinder. It is to be expected that compression diagrams are changed by lubricant additives. This should give itself to recognize in the different section of the force relationship. This study also showed that the lubricant properties of a lubricant can be greatly influenced by the interaction between the lubricant and ingredient formulation to be exposed.