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Background : This study set out to evaluate the ulity of cerebrovascular virtual non-contrast (VNC) scans. Materials and Methods : Convenonal non-contrast (CNC) and dual-energy computed tomography angiography (DE-CTA) head scans were conducted on 100 subjects, of which 46 were normal, 15 had parenchymal hematomas of the brain, 13 had ischemic infarcon, 22 had tumors, and 4 had calcified lesions. VNC images were extracted from the DE-CTA head scans by post-processing. The true (or convenonal) and VNC images were compared in terms of the mean CT a.enuaon value and signal-to-noise rao (SNR) of t he cerebral parenchyma, the image quality, the lesion detecon sensivity, and the radiaon exposure level. Results : The image qualies of the CNC and VNC scans were (4.95 ± 0.22) points and (3.94 ± 0.24) points (t = 31.18, P < 0.05), the mean CT values for the CNC and VNC images were (34.6 ± 2.44) and (28.6 ± 5.40) HU (t = 10.126, P < 0.05), the SNRs were (9.45 ± 1.26) and (6.87 ± 1.77), and the HU for white ma.er was (t = 11.859, P<0.05), respecve ly. The effecve radiaon doses from the DE-CTA head scans and the convenonal non-contrast scans were (8.55 ± 0.57) mSv and (9.41 ± 1.00) mSv, respecvely. No significant difference in the lesion detecon sensivies was ob served between the CNC and VNC scans, except forny calcified lesions, which could not be idenfied by a VNC scan. Conclusion: VNC and contrast-enhanced images could be obtained from DE-CTA head scans and could aid in the diagnosis of cerebral lesions. The radiaon dose from the VNC scan was less than that from the CNC scan.

Clinical applications of virtual, non-contrast head images derived from dual-source, dual-energy cerebrovascular computed tomography angiography