Open AccessDNA demethylating agent decitabine broadens the peripheral T cell receptor repertoire
Author(s) -
Jing Nie,
Yan Zhang,
Xiang Li,
Meixia Chen,
Chuanjie Liu,
Weidong Han
Publication year - 2016
Publication title -
oncotarget
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.373
H-Index - 127
ISSN - 1949-2553
DOI - 10.18632/oncotarget.9352
Subject(s) - decitabine , peripheral , azacitidine , demethylating agent , medicine , dna methylation , cancer research , biology , immunology , genetics , gene , gene expression
Decitabine, a promising epi-immunotherapeutic agent has shown clinical responses in solid tumor patients, while the anti-tumor mechanisms were unclear. We aimed to investigate the immunomodulatory effect of decitabine in peripheral T cells.
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