Dysregulation and functional roles of miR-183-96-182 cluster in cancer cell proliferation, invasion and metastasis | Zendy

Yi Ma | Zendy; Ajuan Liang | Zendy; Yuping Fan | Zendy; Yong Huang | Zendy; Xiaoming Zhao | Zendy; Yun Sun | Zendy; Xiangfeng Chen | Zendy

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Dysregulation and functional roles of miR-183-96-182 cluster in cancer cell proliferation, invasion and metastasis

Author(s) -

Yi Ma,

Ajuan Liang,

Yuping Fan,

Yong Huang,

Xiaoming Zhao,

Yun Sun,

Xiangfeng Chen

Publication year - 2016

Publication title -

oncotarget

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.373

H-Index - 127

ISSN - 1949-2553

DOI - 10.18632/oncotarget.8715

Subject(s) - metastasis , carcinogenesis , cancer , medicine , tumor progression , china , oncology , microrna , cancer research , biology , gene , genetics , history , archaeology

Previous studies have reported aberrant expression of the miR-183-96-182 cluster in a variety of tumors, which indicates its' diagnostic or prognostic value. However, a key characteristic of the miR-183-96-182 cluster is its varied expression levels, and pleomorphic functional roles in different tumors or under different conditions. In most tumor types, the cluster is highly expressed and promotes tumorigenesis, cancer progression and metastasis; yet tumor suppressive effects have also been reported in some tumors. In the present study, we discuss the upstream regulators and the downstream target genes of miR-183-96-182 cluster, and highlight the dysregulation and functional roles of this cluster in various tumor cells. Newer insights summarized in this review will help readers understand the different facets of the miR-183-96-182 cluster in cancer development and progression.

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