Inhibiting cell migration and cell invasion by silencing the transcription factor ETS-1 in human bladder cancer | Zendy

Li Liu | Zendy; Yuchen Liu | Zendy; Xintao Zhang | Zendy; Mingwei Chen | Zendy; Hanwei Wu | Zendy; Muqi Lin | Zendy; Yonghao Zhan | Zendy; Chengle Zhuang | Zendy; Junhao Lin | Zendy; Jianfa Li | Zendy; Wen Xu | Zendy; Xing Fu | Zendy; Qiaoxia Zhang | Zendy; Xiaojuan Sun | Zendy; Guoping Zhao | Zendy; Weiren Huang | Zendy

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Inhibiting cell migration and cell invasion by silencing the transcription factor ETS-1 in human bladder cancer

Author(s) -

Li Liu,

Yuchen Liu,

Xintao Zhang,

Mingwei Chen,

Hanwei Wu,

Muqi Lin,

Yonghao Zhan,

Chengle Zhuang,

Junhao Lin,

Jianfa Li,

Wen Xu,

Xing Fu,

Qiaoxia Zhang,

Xiaojuan Sun,

Guoping Zhao,

Weiren Huang

Publication year - 2016

Publication title -

oncotarget

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.373

H-Index - 127

ISSN - 1949-2553

DOI - 10.18632/oncotarget.7192

Subject(s) - medicine , china , bladder cancer , beijing , gene silencing , cancer , cancer research , oncology , biology , gene , genetics , political science , law

As one of the members of the ETS gene family, the transcription factor v-ets avian erythroblastosis virus E26 oncogene homolog 1 (ETS-1) plays key role in the regulation of physiological processes in normal cells and tumors. In this study, we aimed to investigate the relationship between the transcription factor ETS-1 and malignant phenotypes of bladder cancer. We demonstrated that ETS-1 was up-regulated in human bladder cancer tissue compared to paired normal bladder tissue. In order to evaluate the functional role of ETS-1 in human bladder cancer, vectors expressing ETS-1 shRNA and ETS-1 protein were constructed in vitro and transfected into the human bladder cancer T24 and 5637 cells. Our results showed that the transcription factor ETS-1 could promote cell migration and cell invasion in human bladder cancer, without affecting cell proliferation and apoptosis. In conclusion, ETS-1 plays oncogenic roles through inducing cell migration and invasion in human bladder cancer, and it can be used as a therapeutic target for treating human bladder cancer.

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