Microbiota and bile acid profiles in retinoic acid-primed mice that exhibit accelerated liver regeneration | Zendy

HuiXin Liu | Zendy; Ying Hu | Zendy; YuJui Yvonne Wan | Zendy

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Microbiota and bile acid profiles in retinoic acid-primed mice that exhibit accelerated liver regeneration

Author(s) -

HuiXin Liu,

Ying Hu,

YuJui Yvonne Wan

Publication year - 2015

Publication title -

oncotarget

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.373

H-Index - 127

ISSN - 1949-2553

DOI - 10.18632/oncotarget.6665

Subject(s) - gut flora , bile acid , biology , liver regeneration , hepatocyte , retinoic acid , population , tauroursodeoxycholic acid , taurocholic acid , biochemistry , endocrinology , chemistry , medicine , microbiology and biotechnology , regeneration (biology) , in vitro , apoptosis , gene , environmental health , unfolded protein response

All-trans Retinoic acid (RA) regulates hepatic lipid and bile acid homeostasis. Similar to bile acid (BA), RA accelerates partial hepatectomy (PHx)-induced liver regeneration. Because there is a bidirectional regulatory relationship between gut microbiota and BA synthesis, we examined the effect of RA in altering the gut microbial population and BA composition and established their relationship with hepatic biological processes during the active phases of liver regeneration.

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