Mismatch repair gene defects in sporadic colorectal cancer enhance immune surveillance | Zendy

Marco Scarpa | Zendy; Cesare Ruffolo | Zendy; Fabio Canal | Zendy; Melania Scarpa | Zendy; Silvia Basato | Zendy; Francesca Erroi | Zendy; Alain Fiorot | Zendy; Lucia Dallagnese | Zendy; Anna Pozza | Zendy; Andrea Porzionato | Zendy; Ignazio Castagliuolo | Zendy; Angelo Paolo Dei Tos | Zendy; Nicolò Bassi | Zendy; Carlo Castoro | Zendy

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Mismatch repair gene defects in sporadic colorectal cancer enhance immune surveillance

Author(s) -

Marco Scarpa,

Cesare Ruffolo,

Fabio Canal,

Melania Scarpa,

Silvia Basato,

Francesca Erroi,

Alain Fiorot,

Lucia Dallagnese,

Anna Pozza,

Andrea Porzionato,

Ignazio Castagliuolo,

Angelo Paolo Dei Tos,

Nicolò Bassi,

Carlo Castoro

Publication year - 2015

Publication title -

oncotarget

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.373

H-Index - 127

ISSN - 1949-2553

DOI - 10.18632/oncotarget.6179

Subject(s) - msh2 , cd80 , medicine , msh6 , cancer research , colorectal cancer , immune system , mlh1 , cd8 , tumor infiltrating lymphocytes , foxp3 , dna mismatch repair , immunology , oncology , cancer , biology , cytotoxic t cell , cd40 , in vitro , biochemistry

There is evidence that colorectal cancers (CRC) with DNA mismatch repair deficiency (MMR-D) are associated with a better prognosis than the generality of large bowel malignancies. Since an active immune surveillance process has been demonstrated to influence CRC outcome, we investigated whether MMR-D can enhance the immune response in CRC.

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