microRNAs calibrate T cell responses by regulating mTOR | Zendy

Matthias Merkenschlager | Zendy; Antoine Marçais | Zendy

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microRNAs calibrate T cell responses by regulating mTOR

Author(s) -

Matthias Merkenschlager,

Antoine Marçais

Publication year - 2015

Publication title -

oncotarget

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.373

H-Index - 127

ISSN - 1949-2553

DOI - 10.18632/oncotarget.6107

Subject(s) - t cell receptor , t cell , immune system , microrna , microbiology and biotechnology , biology , pi3k/akt/mtor pathway , immunology , effector , cytokine , acquired immune system , inflammation , signal transduction , gene , genetics

microRNAs are a class of small, non-coding RNAs that regulate gene expression at the post-transcriptional level. By blocking the stability and translation of protein-coding mRNAs, microRNAs impact most biological systems in health and disease, including the development and the function of the immune system [1]. A recent study by Marcais et al. has added new insights how microRNAs guide critical decisions by T lymphocytes [2].

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