Down-regulation of SOSTDC1 promotes thyroid cancer cell proliferation via regulating cyclin A2 and cyclin E2 | Zendy

Weiwei Liang | Zendy; Hongyu Guan | Zendy; Xiaoying He | Zendy; Weijian Ke | Zendy; Lijuan Xu | Zendy; Liehua Liu | Zendy; Haipeng Xiao | Zendy; Yanbing Li | Zendy

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Down-regulation of SOSTDC1 promotes thyroid cancer cell proliferation via regulating cyclin A2 and cyclin E2

Author(s) -

Weiwei Liang,

Hongyu Guan,

Xiaoying He,

Weijian Ke,

Lijuan Xu,

Liehua Liu,

Haipeng Xiao,

Yanbing Li

Publication year - 2015

Publication title -

oncotarget

Language(s) - English

Resource type - Journals

ISSN - 1949-2553

DOI - 10.18632/oncotarget.5566

Subject(s) - thyroid cancer , cancer research , cancer , ectopic expression , cell growth , cyclin , cancer cell , biology , medicine , cell cycle , cell culture , genetics

Sclerostin domain containing protein 1 (SOSTDC1) is down-regulated and acts as a tumor suppressor in some kinds of cancers. However, the expression pattern and biological significance of SOSTDC1 in thyroid cancer are largely unknown. We demonstrated that SOSTDC1 was significantly down-regulated in thyroid cancer. Ectopic over-expression of SOSTDC1 inhibited proliferation and induced G1/S arrest in thyroid cancer cells. Moreover, SOSTDC1 over-expression suppressed the growth of tumor xenografts in nude mice. We also found that elevated SOSTDC1 led to inhibition of cyclin A2 and cyclin E2. Together,our results demonstrate that SOSTDC1 is down-regulated in thyroid cancer and might be a potential therapeutic target in the treatment of thyroid cancer.

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