Mitochondrial ATF2 translocation contributes to apoptosis induction and BRAF inhibitor resistance in melanoma through the interaction of Bim with VDAC1 | Zendy

Zongwei Gao | Zendy; Qingjuan Shang | Zendy; Zhaoyun Liu | Zendy; Chun Deng | Zendy; Chunbao Guo | Zendy

Open Access

Mitochondrial ATF2 translocation contributes to apoptosis induction and BRAF inhibitor resistance in melanoma through the interaction of Bim with VDAC1

Author(s) -

Zongwei Gao,

Qingjuan Shang,

Zhaoyun Liu,

Chun Deng,

Chunbao Guo

Publication year - 2015

Publication title -

oncotarget

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.373

H-Index - 127

ISSN - 1949-2553

DOI - 10.18632/oncotarget.5537

Subject(s) - vdac1 , voltage dependent anion channel , apoptosis , cytochrome c , cancer research , mitochondrion , microbiology and biotechnology , chemistry , biology , biochemistry , escherichia coli , bacterial outer membrane , gene

The mitochondrial accumulation of ATF2 is involved in tumor suppressor activities via cytochrome c release in melanoma cells. However, the signaling pathways that connect mitochondrial ATF2 accumulation and cytochrome c release are not well documented.

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