High expression of CTHRC1 promotes EMT of epithelial ovarian cancer (EOC) and is associated with poor prognosis | Zendy

Minzhi Hou | Zendy; Zhiqiang Cheng | Zendy; Hongwei Shen | Zendy; Shanyang He | Zendy; Li Yang | Zendy; Yunping Pan | Zendy; Chongjin Feng | Zendy; Xinlin Chen | Zendy; Yang Zhang | Zendy; Millicent Lin | Zendy; Liantang Wang | Zendy; Zunfu Ke | Zendy

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High expression of CTHRC1 promotes EMT of epithelial ovarian cancer (EOC) and is associated with poor prognosis

Author(s) -

Minzhi Hou,

Zhiqiang Cheng,

Hongwei Shen,

Shanyang He,

Li Yang,

Yunping Pan,

Chongjin Feng,

Xinlin Chen,

Yang Zhang,

Millicent Lin,

Liantang Wang,

Zunfu Ke

Publication year - 2015

Publication title -

oncotarget

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.373

H-Index - 127

ISSN - 1949-2553

DOI - 10.18632/oncotarget.5358

Subject(s) - vimentin , gene knockdown , cancer research , medicine , wnt signaling pathway , epithelial–mesenchymal transition , metastasis , ectopic expression , cancer , ovarian cancer , oncology , immunohistochemistry , biology , signal transduction , cell culture , biochemistry , genetics

Collagen triple helix repeat-containing 1 (CTHRC1) is aberrantly overexpressed in multiple malignant tumors. However, the expression characteristics and function of CTHRC1 in epithelial ovarian cancer (EOC) remain unclear. We found that CTHRC1 expression was up-regulated in the paraffin-embedded EOC tissues compared to borderline or benign tumor tissues. CTHRC1 expression was positively correlated with tumor size (p = 0.008), menopause (p = 0.037), clinical stage (p = 0.002) and lymph node metastasis (p < 0.001) and was also an important prognostic factor for the overall survival of EOC patients, as revealed by Kaplan-Meier analysis. CTHRC1 increased the invasive capabilities of EOC cells in vitro by activating the Wnt/β-catenin signaling pathway. We showed that ectopic transfection of CTHRC1 in EOC cells up-regulated the expression of EMT markers such as N-cadherin and vimentin, and EMT-associated transcriptional factor Snail. Knockdown of CTHRC1 expression in EOC cells resulted in down-regulation of N-cadherin, vimentin, Snail and translocation of β-catenin. Collectively, CTHRC1 may promote EOC metastasis through the induction of EMT process and serve as a potential biomarker for prognosis as well as a target for therapy.

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