PDK1 induces JunB, EMT, cell migration and invasion in human gallbladder cancer | Zendy

Shixian Lian | Zendy; Yebo Shao | Zendy; Houbao Liu | Zendy; Junyi He | Zendy; Weiqi Lu | Zendy; Yong Zhang | Zendy; Ying Jiang | Zendy; Jun Zhu | Zendy

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PDK1 induces JunB, EMT, cell migration and invasion in human gallbladder cancer

Author(s) -

Shixian Lian,

Yebo Shao,

Houbao Liu,

Junyi He,

Weiqi Lu,

Yong Zhang,

Ying Jiang,

Jun Zhu

Publication year - 2015

Publication title -

oncotarget

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.373

H-Index - 127

ISSN - 1949-2553

DOI - 10.18632/oncotarget.4931

Subject(s) - junb , cancer research , epithelial–mesenchymal transition , metastasis , cancer , cell growth , gallbladder cancer , downregulation and upregulation , medicine , cell , biology , transcription factor , gene , biochemistry , genetics

The protein 3-phosphoinositide-dependent protein kinase 1 (PDK1) is upregulated in cancer. Here we showed that PDK1 stimulated cell proliferation, invasion and metastasis in gallbladder cancer (GBC), by inducing JunB and epithelial-mesenchymal transition. JunB levels were increased in GBC samples and positively correlated with PDK1 levels in tumors. High levels of JunB predicted poor overall survival in GBC patients. Thus, PDK1 functions as a tumor promoter in human GBC by upregulating JunB.

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