Splenocytes derived from young WT mice prevent AD progression in APPswe/PSENldE9 transgenic mice | Zendy

Fei Wang | Zendy; Xueyan Shen | Zendy; Shuping Li | Zendy; Long Chen | Zendy; Yanru Wang | Zendy; Jie Qin | Zendy; Guomin Zhou | Zendy; Yuwen Peng | Zendy; Xiaoyuan Feng | Zendy; Ruixi Li | Zendy; Chunmin Liang | Zendy

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Splenocytes derived from young WT mice prevent AD progression in APPswe/PSENldE9 transgenic mice

Author(s) -

Fei Wang,

Xueyan Shen,

Shuping Li,

Long Chen,

Yanru Wang,

Jie Qin,

Guomin Zhou,

Yuwen Peng,

Xiaoyuan Feng,

Ruixi Li,

Chunmin Liang

Publication year - 2015

Publication title -

oncotarget

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.373

H-Index - 127

ISSN - 1949-2553

DOI - 10.18632/oncotarget.4930

Subject(s) - splenocyte , medicine , genetically modified mouse , immune system , transgene , immunology , astrogliosis , biology , biochemistry , gene , central nervous system

Immunosenescence contributes to pathogenesis of Alzheimer's disease (AD) in the elderly. In this study, we explored the effects of young wild type (WT) splenocytes (ySCs) on Alzheimer's disease by transplanting ySCs into APPswe/PSENldE9 transgenic mice. Young WT splenocytes not only prevented AD, but also improved the spatial learning and memory of APPswe/PSENldE9 transgenic mice. Young WT splenocytes enhanced Aβ clearance, decreased astrogliosis and increased systemic growth differentiation factor 11 (GDF11) levels. Splenocytes derived from old AD mouse promoted AD. There was an increased number of regulatory T cells (Tregs) among old AD splenocytes. We suggest that alterations of GDF11 and Tregs are involved in AD progression and that rejuvenation of the immune system is a potential therapeutic strategy in AD.

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