Na+-induced Ca2+ influx through reverse mode of Na+-Ca2+ exchanger in mouse ventricular cardiomyocyte | Zendy

Zhen-Yu Yan | Zendy; Tao Ban | Zendy; Yao Fan | Zendy; Wei-Ran Chen | Zendy; Hong-Li Sun | Zendy; Hanying Chen | Zendy; Quo-Fen Qiao | Zendy; BaiYan Li | Zendy

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Na+-induced Ca2+ influx through reverse mode of Na+-Ca2+ exchanger in mouse ventricular cardiomyocyte

Author(s) -

Zhen-Yu Yan,

Tao Ban,

Yao Fan,

Wei-Ran Chen,

Hong-Li Sun,

Hanying Chen,

Quo-Fen Qiao,

BaiYan Li

Publication year - 2015

Publication title -

oncotarget

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.373

H-Index - 127

ISSN - 1949-2553

DOI - 10.18632/oncotarget.4878

Subject(s) - dobutamine , inotrope , depolarization , medicine , chemistry , repolarization , electrophysiology , stimulation , sodium calcium exchanger , endocrinology , cardiology , calcium , hemodynamics

Dobutamine is commonly used for clinical management of heart failure and its pharmacological effects have long been investigated as inotropics via β-receptor activation. However, there is no electrophysiological evidence if dobutamine contributes inotropic action due at least partially to the reverse mode of Na+-Ca2+ exchanger (NCX) activation.

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