Critical role of bevacizumab scheduling in combination with pre-surgical chemo-radiotherapy in MRI-defined high-risk locally advanced rectal cancer: results of the branch trial | Zendy

Antonio Avallone | Zendy; Biagio Pecori | Zendy; Francesco Bianco | Zendy; Luigi Aloj | Zendy; Fabiana Tatangelo | Zendy; Carmela Romano | Zendy; Vincenza Granata | Zendy; P. Marone | Zendy; Alessandra Leone | Zendy; Gerardo Botti | Zendy; Antonella Petrillo | Zendy; Corradina Caracò | Zendy; Vincenzo Rosario Iaffaioli | Zendy; Paolo Muto | Zendy; G. Romano | Zendy; Pasquale Comella | Zendy; Alfredo Budillon | Zendy; Paolo Delrio | Zendy

Open Access

Critical role of bevacizumab scheduling in combination with pre-surgical chemo-radiotherapy in MRI-defined high-risk locally advanced rectal cancer: results of the branch trial

Author(s) -

Antonio Avallone,

Biagio Pecori,

Francesco Bianco,

Luigi Aloj,

Fabiana Tatangelo,

Carmela Romano,

Vincenza Granata,

P. Marone,

Alessandra Leone,

Gerardo Botti,

Antonella Petrillo,

Corradina Caracò,

Vincenzo Rosario Iaffaioli,

Paolo Muto,

G. Romano,

Pasquale Comella,

Alfredo Budillon,

Paolo Delrio

Publication year - 2015

Publication title -

oncotarget

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.373

H-Index - 127

ISSN - 1949-2553

DOI - 10.18632/oncotarget.4724

Subject(s) - medicine , nuclear medicine

We have previously shown that an intensified preoperative regimen including oxaliplatin plus raltitrexed and 5-fluorouracil/folinic acid (OXATOM/FUFA) during preoperative pelvic radiotherapy produced promising results in locally advanced rectal cancer (LARC). Preclinical evidence suggests that the scheduling of bevacizumab may be crucial to optimize its combination with chemo-radiotherapy.

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