Combination of electroporation delivered metabolic modulators with low-dose chemotherapy in osteosarcoma | Zendy

Kheshwant S. Gill | Zendy; Philana Fernandes | Zendy; Brian Bird | Zendy; Declan M. Soden | Zendy; Patrick F. Forde | Zendy

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Combination of electroporation delivered metabolic modulators with low-dose chemotherapy in osteosarcoma

Author(s) -

Kheshwant S. Gill,

Philana Fernandes,

Brian Bird,

Declan M. Soden,

Patrick F. Forde

Publication year - 2018

Publication title -

oncotarget

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.373

H-Index - 127

ISSN - 1949-2553

DOI - 10.18632/oncotarget.25843

Subject(s) - osteosarcoma , medicine , chemotherapy , electroporation , cancer research , cisplatin , oncology , pharmacology , biology , biochemistry , gene

Osteosarcoma accounts for roughly 60% of all malignant bone tumors in children and young adults. The five-year survival rate for localized tumors after surgery and chemotherapy is approximately 70% whilst it drastically reduces to 15-30% in metastatic cases. Metabolic modulation is known to increase sensitivity of cancers to chemotherapy. A novel treatment strategy in Osteosarcoma is needed to battle this devastating malady.

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