Porphyrin photosensitizers in photodynamic therapy and its applications | Zendy

Jiayuan Kou | Zendy; Dou Dou | Zendy; Liming Yang | Zendy

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Porphyrin photosensitizers in photodynamic therapy and its applications

Author(s) -

Jiayuan Kou,

Dou Dou,

Liming Yang

Publication year - 2017

Publication title -

oncotarget

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.373

H-Index - 127

ISSN - 1949-2553

DOI - 10.18632/oncotarget.20189

Subject(s) - photodynamic therapy , photosensitizer , hematoporphyrin , medicine , porphyrin , cancer research , physiology , chemistry , biochemistry , organic chemistry

In 1841, the extraction of hematoporphyrin from dried blood by removing iron marked the birth of the photosensitizer. The last twenty years has witnessed extensive research in the application of photodynamic therapy (PDT) in tumor-bearing (or other diseases) animal models and patients. The period has seen development of photosensitizers from the first to the third generation, and their evolution from simple to more complex entities. This review focuses on porphyrin photosensitizers and their effect on tumors, mediated via several pathways involved in cell necrosis, apoptosis or autophagic cell death, and the preventive and therapeutic application of PDT against atherosclerosis.

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