FOXP3 inhibits cancer stem cell self-renewal via transcriptional repression of COX2 in colorectal cancer cells | Zendy

Shuo Liu | Zendy; Cun Zhang | Zendy; Kuo Zhang | Zendy; Yuan Gao | Zendy; Zhaowei Wang | Zendy; Xiaoju Li | Zendy; Guang Cheng | Zendy; Shuning Wang | Zendy; Xiaochang Xue | Zendy; Weina Li | Zendy; Wei Zhang | Zendy; Yingqi Zhang | Zendy; Xianghui Xing | Zendy; Meng Li | Zendy; Qiang Hao | Zendy

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FOXP3 inhibits cancer stem cell self-renewal via transcriptional repression of COX2 in colorectal cancer cells

Author(s) -

Shuo Liu,

Cun Zhang,

Kuo Zhang,

Yuan Gao,

Zhaowei Wang,

Xiaoju Li,

Guang Cheng,

Shuning Wang,

Xiaochang Xue,

Weina Li,

Wei Zhang,

Yingqi Zhang,

Xianghui Xing,

Meng Li,

Qiang Hao

Publication year - 2017

Publication title -

oncotarget

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.373

H-Index - 127

ISSN - 1949-2553

DOI - 10.18632/oncotarget.17974

Subject(s) - medicine , cancer , zhàng , cancer stem cell , cancer research , oncology , china , political science , law

Colon cancer stem cell (cCSC) is considered as the seed cell of colon cancer initiation and metastasis. Cyclooxygenase-2 (COX2), a downstream target of NFκB, is found to be essential in promoting cancer stem cell renewal. However, how COX2 is dysregulated in cCSCs is largely unknown. In this study, we found that the expression of transcription factor FOXP3 was much lower in the spheroids than that in the parental tumor cells. Overexpression of FOXP3 significantly decreased the numbers of spheres, reduced the side population. Accordingly, FOXP3 expression decreased the tumor size and weight in the xenograft model. The tumor inhibitory effects of FOXP3 were rarely seen when COX2 was additionally knocked down. Mechanically, FOXP3 transcriptionally repressed COX2 expression via interacting with and thus inhibiting p65 activity on the putative NFκB response elements in COX2 promoter. Taken together, we here revealed possible involvement of FOXP3 in regulating cCSC self-renewal via tuning COX2 expression, and thus providing a new target for the eradication of colon cancer stem cells.

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