NGS based identification of mutational hotspots for targeted therapy in anaplastic thyroid carcinoma | Zendy

Vera Tiedje | Zendy; Saskia Ting | Zendy; Thomas Herold | Zendy; S. Synoracki | Zendy; Soeren Latteyer | Zendy; Lars C. Moeller | Zendy; Denise Zwanziger | Zendy; Martin Stuschke | Zendy; Dagmar Fuehrer | Zendy; Kurt Werner Schmid | Zendy

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NGS based identification of mutational hotspots for targeted therapy in anaplastic thyroid carcinoma

Author(s) -

Vera Tiedje,

Saskia Ting,

Thomas Herold,

S. Synoracki,

Soeren Latteyer,

Lars C. Moeller,

Denise Zwanziger,

Martin Stuschke,

Dagmar Fuehrer,

Kurt Werner Schmid

Publication year - 2017

Publication title -

oncotarget

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.373

H-Index - 127

ISSN - 1949-2553

DOI - 10.18632/oncotarget.17300

Subject(s) - medicine , neuroblastoma ras viral oncogene homolog , context (archaeology) , kras , thyroid cancer , cancer , targeted therapy , oncology , thyroid carcinoma , hras , cancer research , thyroid , biology , colorectal cancer , paleontology

Anaplastic thyroid carcinoma (ATC) represents one of the most aggressive carcinomas with no consistent survival benefit when treated with conventional radiochemotherapy. Approaches targeting "oncogene addiction" of ATC are increasingly explored and first promising results have been reported in single case studies.

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