Local recurrences at the anastomotic area are clonally related to the primary tumor in sporadic colorectal carcinoma | Zendy

Efsevia Vakiani | Zendy; Ronak Shah | Zendy; Michael F. Berger | Zendy; Alvin MakohonMoore | Zendy; Johannes G. Reiter | Zendy; Irina Ostrovnaya | Zendy; Marc A. Attiyeh | Zendy; Andrea Cercek | Zendy; Jinru Shia | Zendy; Christine A. IacobuzioDonahue | Zendy; David B. Solit | Zendy; Martin R. Weiser | Zendy

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Local recurrences at the anastomotic area are clonally related to the primary tumor in sporadic colorectal carcinoma

Author(s) -

Efsevia Vakiani,

Ronak Shah,

Michael F. Berger,

Alvin MakohonMoore,

Johannes G. Reiter,

Irina Ostrovnaya,

Marc A. Attiyeh,

Andrea Cercek,

Jinru Shia,

Christine A. IacobuzioDonahue,

David B. Solit,

Martin R. Weiser

Publication year - 2017

Publication title -

oncotarget

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.373

H-Index - 127

ISSN - 1949-2553

DOI - 10.18632/oncotarget.17200

Subject(s) - kras , colorectal cancer , metastasis , cancer research , microsatellite , mutation , microsatellite instability , primary tumor , medicine , biology , gene , oncology , cancer , genetics , allele

Anastomotic recurrences (AR) occur in 2-10% of colorectal carcinoma cases after resection of primary tumor (PT). Currently, there are no molecular data investigating their genetic profile and multiple theories exist about their pathogenesis. The aim of our study was to compare the genomic profile of AR to that of the patients' corresponding matched PT and, when available, to a distant metastasis (DM).

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