Long non-coding RNAs in renal cell carcinoma: A systematic review and clinical implications | Zendy

Ming Li | Zendy; Ying Wang | Zendy; Liang Cheng | Zendy; Wanting Niu | Zendy; Guoan Zhao | Zendy; Jithin K. Raju | Zendy; Huo Jun | Zendy; Bin Wu | Zendy; Bo Yin | Zendy; Yongsheng Song | Zendy; Renge Bu | Zendy

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Long non-coding RNAs in renal cell carcinoma: A systematic review and clinical implications

Author(s) -

Ming Li,

Ying Wang,

Liang Cheng,

Wanting Niu,

Guoan Zhao,

Jithin K. Raju,

Huo Jun,

Bin Wu,

Bo Yin,

Yongsheng Song,

Renge Bu

Publication year - 2017

Publication title -

oncotarget

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.373

H-Index - 127

ISSN - 1949-2553

DOI - 10.18632/oncotarget.17053

Subject(s) - renal cell carcinoma , malignancy , carcinogenesis , long non coding rna , kidney cancer , computational biology , bioinformatics , medicine , biology , cancer , rna , cancer research , oncology , gene , genetics

Renal cell carcinoma is one of the most common malignancy in adults, its prognosis is poor in an advanced stage and early detection is difficult due to the lack of molecular biomarkers. The identification of novel biomarkers for RCC is an urgent and meaningful project. Long non-coding RNA (lncRNA) is transcribed from genomic regions with a minimum length of 200 bases and limited protein-coding potential. Recently, lncRNAs have been greatly studied in a variety of cancer types. They participate in a wide variety of biological processes including cancer biology. In this review, we provide a new insight of the profiling of lncRNAs in RCC and their roles in renal carcinogenesis, with an emphasize on their potential in diagnosis, prognosis and potential roles in RCC therapy.

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